Treatment of Aplastic Anemia.

ALLOGENIC BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA

Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...

Aplastic anemia evolving to myelodysplastic syndrome and later to a lymphoproliferative malignancy in a treated case of carcinoma breast: A case report emphasizing the importance of PET-CT in cutaneous T cell lymphoma

Although aplastic anemia (AA) and myelodysplastic syndrome (MDS) are separate entities with different management, distinction between the two can be difficult on morphological basis due to hypocellularity of bone marrow. MDS is one of the serious complications of AA. Karyotyping is definitive in the diagnosis of MDS. Better and robust investigations like 18F-Fluoro-deoxy-Glucose Posi...

False Negativity of Tc-99m Labeled Sodium Phytate Bone Marrow Imaging Under the Effect of G-CSF Prescription in Aplastic Anemia: A Case Report

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine which controls the differentiation and growth of hematopoietic cells in the bone marrow. We report a severe aplastic anemia (SAA) patient with false-negative 99mTc sodium phytate bone marrow imaging findings under concurrent G-CSF therapy. The first bone marrow imaging showed a normal bone marrow activity. However, the bo...

CURRENT CONCEPTS IN THE PATHOPHYSIOLOGY AND TREATMENT OF APLASTIC ANEMIA Running head: Current concepts in aplastic anemia

تعیین میزان بقا و عوامل موثر بر آن در کودکان مبتلا به آنمی آپلاستیک اکتسابی

Aplastic anemia is a clinical syndrome in which there is peripheral blood pancytopenia due to reduced or absent production of blood cells without evidence of another marrow disorder. The disorder may be acquired or inherited like Fanconi’s anemia. In this study, survial and prognostic factors in acquired aplastic anemia is determined. This analytic cross-sectional study was done on 224 ...

Iron chelation effect of curcumin and baicalein on aplastic anemia mouse model with iron overload

Objective(s): The current work aimed to assess whether curcumin and baicalein can chelate iron in aplastic anemia (AA) complicated with iron overload, exploring the potential mechanisms.Materials and Methods: A mouse model of AA with iron overload complication was firstly established. Low and high-dose curcumin or baicalein treatment gro...